See annual publication for most recent information. Naphthalene: general information - GOV.UK Terminal Body Weights in Controls and in Fischer 344 Rats Exposed to Naphthalene by Gavage for 13 Weeks 7-8 Table 7-2. . . Poison - Naphthalene poisoning - ADAM Breathing Trouble. Symptoms of naphthalene poisoning include headache, dizziness, nausea, and fatigue. Naphthalene Technical Fact Sheet - Oregon State University Acute (short-term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. . Acute naphthalene toxicity presenting with metabolic acidosis: a rare DO NOT use it to treat or manage an actual poison exposure. Hemolytic anemia and methemoglobinemia are . . Naphthalene Poisoning During a Decade: A Retrospective Clinical Study Naphthalene is a white solid substance with a strong smell. Intentional naphthalene poisoning is very rare and we could not find many reports in the literature of suicidal naphthalene poisoning. It is also found in transparent to brownish color. Acute Toxicity 3.3.1.1. What does naphthalene do to humans? Naphthalene poisoning - Wikipedia DO NOT use it to treat or manage an actual poison exposure. In mice, the injury is dose-dependent and Clara cell-specific. Naphthalene is a polycyclic aromatic hydrocarbon (PAH), but exposure here is intended to . Naphthalene 91-20-3 Hazard Summary Naphthalene is used in the production of phthalic anhydride; it is also used in mothballs. The common manifestations are confusion, restlessness, delirium, and hallucinations, muscle twitching, myoclonus, ataxia, hyperreflexia, fasciculations, and seizures. The Risk Assessment Information System . Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. As an aromatic hydrocarbon, naphthalene's structure consists of a fused pair of benzene rings. A 33-year-old Sri Lankan woman presented to us 2 days . Classied as a Group C, possible human carcinogen. Is Naphthalene Toxic to Humans? - Stamina Comfort Introduction Naphthalene is commonly found in moth repellent products such as mothballs in developing countries. The final rule retains this TWA and adds a short-term limit of 15 ppm for this substance . Incidence and Severity of Nonneoplastic Lesions in the Noses of Rats in a CDC - NIOSH Pocket Guide to Chemical Hazards - Naphthalene NA inhalation exposure induces the expression of several genes or pathways related to lung tumor . Naphthalene is a primary irritant upon direct skin contact and may be acutely irritating to the eyes. Accidental or intentional poisoning by naphthalene has been reported by swallowing, skin contact, and inhalation. NAPHTHALENE | Occupational Safety and Health Administration To The most likely source of exposure to significant amounts of naphthalene is occupational inhalation of the vapour, since its principal use is in industry [1]. Seek medical assistance to ensure that regular breathing is re-established. OSHA's former exposure limit for naphthalene was 10 ppm as an 8-hour TWA. Acute lung toxicity and carcinogenesis are thought to be related because the target sites for both are similar. Naphthalene Methemoglobinemia Hemolytic anemia Metabolic acidosis Seizures 1. The metabolite of naphthalene (usually -naphthol) is the main cause of poisoning. What color is naphthalene? This article is for information only. Environmental Eects: Moderate to low mobility in soil. 3.3. Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. PDF Naphthalene - US EPA Naphthalene poisoning: MedlinePlus Medical Encyclopedia 22 Rats, however, were unaffected following inhalation exposure to naphthalene for four hours . Acute exposure can even lead to temporary blindness or cataracts. Naphthalene has been found in wastewater treatment plant discharge. If you or someone you are with has an exposure, call your local . If you or someone you are with has an exposure, call your local . PDF Designation Of Naphthalene As A Carcinogen: Risk Assessment For Naphthalene is generally white in color. As little as one mothball can result in toxicity in children. NAPHTHALENE (IARC Summary & Evaluation, Volume 82, 2002) Coughing, wheezing and shortness of breath are all common side effects of moth ball inhalation. The woman, her 4-year-old daughter, and seven relatives living in two other households where mothballs were extensively used, had symptoms and medical findings compatible with naphthalene exposure--headache, nausea, vomiting, abdominal pain, malaise, confusion, anemia, icterus, and renal disease. It is best known as the main ingredient of traditional mothballs Ingestion, either accidental or by deliberate self-harm, can occur due to its abundance as well as its candy-resembling appearance. Human exposure to naphthalene (NA), an acute lung toxicant and possible human carcinogen, is primarily through inhalation. Naphthalene exposure has been associated with cancer and noncancer health effects, with most of the evidence coming from animal studies and human case studies (ATSDR 2005; U.S. EPA 1998). OTHER ROUTES OF EXPOSURE 3.3.1. Technical Report Series No. Naphthalene is toxic to humans through ingestion or inhalation. Naphthalene is broken down by bacteria, fungi, air, and sunlight. This article is for information only. Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. from incomplete combustion) and/or indoor air (i.e. This can cause organ damage. View complete answer on epa.gov. The most reliable human data available come from a controlled skin exposure study, but the inhalation PBPK model does not include a skin exposure route; therefore, we extended the model . Long-term exposure to low levels of naphthalene may increase your risk of developing cancer. A reference concentration (RfC) for inhalation exposure to naphthalene has not been derived (U.S. EPA, 1991, 1992). 1-3, p. 420 . Exposure to large amounts of naphthalene may damage or destroy red blood cells. Acute (short- term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. ACGIH: Documentation of the Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) - Naphthalene. Diarrhea can indicate naphthalene poisoning. This article is for information only. from mothballs). Acute (short- term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. (APF = 10) Any air-purifying half-mask respirator with organic vapor cartridge (s) in combination with an N95, R95, or P95 filter. Those with glucose-6-phosphate dehydrogenase (G6PD) deficiency are especially susceptible. What is naphthalene in chemistry? - vanjava.norushcharge.com Naphthalene is a white solid substance with a strong smell. The following filters may also be used: N99, R99, P99, N100, R100, P100. Naphthalene General Fact Sheet - Oregon State University A Physiologically Based Pharmacokinetic Model for Naphthalene With [citation needed] Naphthalene was introduced in 1841 by Rossbach as an antiseptic to counteract typhoid fever.Although naphthalene was widely used industrially, only nine cases of poisoning have been reported since 1947 as of 1956 . CAREX defines exposure to naphthalene as inhalation exposure at work at levels exceeding those encountered in non-occupational settings, such as exposure due to inhaling urban air (i.e. NIH Publication No. Human. (1992). This article is for information only. DO NOT use it to treat or manage an actual poison exposure. Diapers and clothing stored with mothballs have caused skin . Naphthalene has been detected in untreated ambient ground water samples. This is because it is a known carcinogen that can bind to DNA and cause mutations that lead to cancer . Acute (short- term) exposure of humans to naphthalene by inhalation, ingestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage.Cataracts have also been reported in workers acutely exposed to naphthalene by inhalation and ingestion. 92-3141. Naphthalene is an organic compound with formula C 10 H 8.It is the simplest polycyclic aromatic hydrocarbon, and is a white crystalline solid with a characteristic odor that is detectable at concentrations as low as 0.08 ppm by mass. retina. Health Effects of Naphthalene Exposure: A Systematic Evidence Map and Clinically, patients present with acute onset of dark brown urine, watery diarrhea, and non-bloody bilious vomiting 48-96 hours after exposure. Headache, nausea, vomiting, abdominal cramps . However, the general public may be exposed to naphthalene through inhalation of smoke from burning fossil fuels or wood, or from inhaling vehicle exhaust fumes. The prognosis of Naphthalene Poisoning is dependent on the amount of substance consumed, time between exposure and treatment, severity of the symptoms, as well as general health status of the patient If the individual can recover from the symptoms, with appropriate medication and prompt medical support, the outcome can be good. Naphthalene inhalation exposure is well known to produce respiratory lesions, so lack of reported blinding was flagged as a potential concern in studies . Most naphthalene in the environment will turn into a gas. NIOSH/OSHA. Though it is freely available around this country, poisoning has never been reported in the literature. Exposure to Naphthalene in Media Other than Water 5-8 Table 7-1. It can also be deposited on plant leaves from the air. Naphthalene causes lung toxicity in mice, but not rats, following either intraperitoneal injection or inhalation exposure. This can cause organ damage. NTP: Toxicology and carcinogenesis studies of naphthalene in B6C3F1 mice (inhalation studies). Naphthalene is a white solid substance with a strong smell. First Aid for Naphthalene Poisoning - DoveMed Illness Associated with Exposure to Naphthalene in Mothballs -- Indiana PDF NAPHTHALENE Toxicological Overview v1 - GOV.UK The onset of action is very rapid (5-15 minutes). This can cause organ damage. Severe poisoning can result in haemolytic anaemia. Sources and route of human exposure Naphthalene toxicity may occur by all routes of exposure, whether by inhalation of vapours, ingestion and by dermal or ocular contact [1-3]. Humans, particularly children, have developed hemolytic anemia after ingesting mothballs or deodorant blocks containing naphthalene. Even small doses of camphor can cause serious toxicity and is potentially fatal. It is well absorbed following oral, dermal and inhalation exposure. Kerosene, Camphor, and Naphthalene Poisoning in Children 1-995; Patty 1949b, as cited in ACGIH 1986/Ex. A published inhalation PBPK model for naphthalene was previously shown to predict rodent PK data well, so we sought to evaluate this model using human PK data. Poisoning from naphthalene destroys or changes red blood cells so they cannot carry oxygen. 21 Clara cells are nonciliated bronchiolar cells containing P450 enzymes, the makeup and distribution of which are species dependent. Some of it may be bound to soil, where it can be taken up by plants. Naphthalene - Occupational Exposures - CAREX Canada If you or someone you are with has an exposure, call your local . Use of naphthalene balls as chronic inhalant abuse was however reported by Weintraub et al., which was associated with chronic neuropathy and chronic renal failure. In humans, the inhalation of naphthalene vapor causes headache, loss of appetite, and nausea (Flury and Zernik 1931g/Ex. Where can naphthalene be found? - sitillc.dixiesewing.com A Physiologically Based Pharmacokinetic Model for Naphthalene With Naphthalene is a white solid substance with a strong smell. Exposure to naphthalene commonly causes headache, nausea, vomiting, diarrhea, abdominal pain, fever, and altered mental status. Naphthalene Poisoning. tonga volcano eruption again biomedical science jobs san diego 813-731-9283 Looking for a Shuttle in the Tampa Bay Area? Naphthalene (mothball) is a commonly used deodorizer in the Indian subcontinent, including Sri Lanka. Naphthalene Poisoning Manifesting as Hemoglobinuria - PMC PDF C hemicalWatch Factsheet - Beyond Pesticides Diarrhea. Naphthalene (NA) was shown to be carcinogenic, causing respiratory epithelial adenoma in the nasal cavity of male F344 rats and olfactory epithelial neuroblastoma in female F344 rats at exposure concentrations of 10-60 ppm in a 2-year inhalation study conducted by the National Toxicology Program. Acute intravascular hemolysis due to naphthalene toxicity: a case Mice exposed to 2 ppm naphthalene vapors for four hours exhibited damage to the Clara cells of the proximal airways. Where can naphthalene be found? Explained by FAQ Blog naphthalene inhalation exposure - expresstransportationnow.com 1988 OSHA PEL Project - Naphthalene | NIOSH | CDC The . Cataracts have also been reported in workers acutely exposed to naphthalene by inhalation and ingestion. Naphthalene - Wikipedia DESIGNATION OF NAPHTHALENE AS A CARCINOGEN: RISK ASSESSMENT FOR INHALATION EXPOSURE PATHWAYS AT HAZARDOUS WASTE SITES J P Christopher, B K Davis, J M Polisini, and M J Wade, California Department of Toxic Substances Control, Sacramento Presented at: 44th Annual Meeting of the Society of Toxicology New Orleans, Louisiana 10 March 2005 Metabolism and Lung Toxicity of Inhaled Naphthalene: Effects of DO NOT use it to treat or manage an actual poison exposure. 410. (APF = 50) Any air-purifying full-facepiece respirator equipped . Nasal epithelial lesions in F344 rats following a 90-day inhalation Naphthalene poisoning (or mothball poisoning) is a form of poisoning that occurs when naphthalene is ingested. Naphthalene poisoning | UF Health, University of Florida Health This can cause organ damage. Naphthalene, a volatile organic compound found in moth repellants and petroleum-based fuels, has been shown to induce respiratory tract toxicity in both mice and rats during chronic inhalation exposures (NTP, 1992, 2000).Two-year inhalation studies demonstrated carcinogenicity in the form of increased incidence of nasal respiratory epithelium adenomas in male rats and olfactory epithelial . Naphthalene Poisoning - The Anti-Aging Medical Clinic Naphthalene poisoning is a rare form of toxicity that may occur after ingestion, inhalation, or dermal exposure to naphthalene-containing compounds such as mothballs. Exposure to naphthalene. Cataracts have also been reported in If you or someone you are with has an exposure, call your local . Click here for information on selection of N, R, or P filters.*. The Effects of Inhaling Moth Balls - SportsRec Camphor poisoning is not very common in childhood. Naphthalene Toxicity: Methemoglobinemia and Acute Intravascular PDF Health Effects Support Document for Naphthalene, February 2003. - US EPA Exposed to Naphthalene by Inhalation for Their Lifetime 7-15 Table 7-4. Naphthalene poisoning Information | Mount Sinai - New York After repeated administration of naphthalene, mouse Clara cells become tolerant to the naphthalene-induced injury that occurs following a single dose of . Acute exposure to naphthalene by inhalation, in-gestion, and dermal contact is associated with hemolytic anemia, damage to the liver, and neurological damage. Vital sign abnormalities include . 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